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Anti-CD38 antibodies mediate anti-myeloma activity through multiple mechanisms of action both in patients with RRMM and with newly diagnosed MM, although immunomodulatory effects may be greater in earlier disease settings in which the immune system has not been affected by prior treatments [85]

In certain embodiments, the amount of sodium kenodeoxycholate is about 100 mg, about 200 mg, about 300 mg, about 400 mg, about 500 mg, about 600 mg, about 700 mg, or about 800 mg